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HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na(+)-H(+) exchangers
Hepatocyte growth factor (HGF) is found in tumor microenvironments, and interaction with its tyrosine kinase receptor Met triggers cell invasion and metastasis. It was previously shown that acidic extracellular pH stimulated peripheral lysosome trafficking, resulting in increased cathepsin B secreti...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Company of Biologists
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844323/ https://ncbi.nlm.nih.gov/pubmed/20215403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.063644 |
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