Control of Steroid 21-oic Acid Synthesis by Peroxisome Proliferator-activated Receptor α and Role of the Hypothalamic-Pituitary-Adrenal Axis

A previous study identified the peroxisome proliferator-activated receptor α (PPARα) activation biomarkers 21-steroid carboxylic acids 11β-hydroxy-3,20-dioxopregn-4-en-21-oic acid (HDOPA) and 11β,20-dihydroxy-3-oxo-pregn-4-en-21-oic acid (DHOPA). In the present study, the molecular mechanism and the...

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Hlavní autoři: Wang, Ting, Shah, Yatrik M., Matsubara, Tsutomu, Zhen, Yueying, Tanabe, Tomotaka, Nagano, Tomokazu, Fotso, Serge, Krausz, Kristopher W., Zabriskie, T. Mark, Idle, Jeffrey R., Gonzalez, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844213/
https://ncbi.nlm.nih.gov/pubmed/20032461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090175
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