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A Residue in Loop 9 of the β2-Subunit Stabilizes the Closed State of the GABA(A) Receptor
In γ-aminobutyric acid type A (GABA(A)) receptors, the structural elements that couple ligand binding to channel opening remain poorly defined. Here, site-directed mutagenesis was used to determine if Loop 9 on the non-GABA binding site interface of the β2-subunit may be involved in GABA(A) receptor...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844176/ https://ncbi.nlm.nih.gov/pubmed/20007704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050294 |
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