Conformational Changes Induced in Voltage-gated Calcium Channel Cav1.2 by BayK 8644 or FPL64176 Modify the Kinetics of Secretion Independently of Ca(2+) Influx

The role of the L-type calcium channel (Cav1.2) as a molecular switch that triggers secretion prior to Ca(2+) transport has previously been demonstrated in bovine chromaffin cells and rat pancreatic beta cells. Here, we examined the effect of specific Cav1.2 allosteric modulators, BayK 8644 (BayK) a...

Full description

Saved in:
Bibliographic Details
Main Authors: Marom, Merav, Hagalili, Yamit, Sebag, Ariel, Tzvier, Lior, Atlas, Daphne
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844149/
https://ncbi.nlm.nih.gov/pubmed/20054004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059865
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items