Acute Acidification of Stratum Corneum Membrane Domains Using Polyhydroxyl Acids Improves Lipid Processing and Inhibits Degradation of Corneodesmosomes

Neutralization of the normally acidic stratum corneum (SC) has deleterious consequences for permeability barrier homeostasis and SC integrity/cohesion attributable to serine proteases (SPs) activation leading to deactivation/degradation of lipid-processing enzymes and corneodesmosomes (CD). As an el...

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Autors principals: Hachem, Jean-Pierre, Roelandt, Truus, Schürer, Nanna, Pu, Xu, Fluhr, Joachim, Giddelo, Christina, Man, Mao-Qiang, Crumrine, Debra, Roseeuw, Diane, Feingold, Kenneth R., Mauro, Theodora, Elias, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844116/
https://ncbi.nlm.nih.gov/pubmed/19741713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.249
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