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Dimensionality Controls Cytoskeleton Assembly and Metabolism of Fibroblast Cells in Response to Rigidity and Shape

BACKGROUND: Various physical parameters, including substrate rigidity, size of adhesive islands and micro-and nano-topographies, have been shown to differentially regulate cell fate in two-dimensional (2-D) cell cultures. Cells anchored in a three-dimensional (3-D) microenvironment show significantl...

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Detalhes bibliográficos
Main Authors: Ochsner, Mirjam, Textor, Marcus, Vogel, Viola, Smith, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843632/
https://ncbi.nlm.nih.gov/pubmed/20351781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009445
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