Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure.

In vitro studies of zidovudine (ZDV) phosphorylation may not accurately reflect the in vivo dose-response relationship, which is crucial to determining the relationship between ZDV exposure, efficacy, and toxicity. However, measurement of ZDV phosphorylated anabolites in peripheral blood mononuclear...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Slusher, J T, Kuwahara, S K, Hamzeh, F M, Lewis, L D, Kornhauser, D M, Lietman, P S
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 1992
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284356/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1489190/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.11.2473
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