Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure.

In vitro studies of zidovudine (ZDV) phosphorylation may not accurately reflect the in vivo dose-response relationship, which is crucial to determining the relationship between ZDV exposure, efficacy, and toxicity. However, measurement of ZDV phosphorylated anabolites in peripheral blood mononuclear...

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Bibliographic Details
Main Authors: Slusher, J T, Kuwahara, S K, Hamzeh, F M, Lewis, L D, Kornhauser, D M, Lietman, P S
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC284356/
https://ncbi.nlm.nih.gov/pubmed/1489190
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