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Single Mutations Change CYP2F3 From a Dehydrogenase of 3-Methylindole to an Oxygenase
Pulmonary cytochrome P450 2F3 (CYP2F3) catalyzes the dehydrogenation of the pneumotoxin 3-methylindole (3MI) to an electrophilic intermediate, 3-methyleneindolenine, which is responsible for the toxicity of the parent compound. Members of the CYP2F subfamily are the only enzymes known to exclusively...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2843524/ https://ncbi.nlm.nih.gov/pubmed/18717595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8005658 |
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