Neuropilin 1 Directly Interacts with Fer Kinase to Mediate Semaphorin 3A-induced Death of Cortical Neurons

Neuropilins (NRPs) are receptors for the major chemorepulsive axonal guidance cue semaphorins (Sema). The interaction of Sema3A/NRP1 during development leads to the collapse of growth cones. Here we show that Sema3A also induces death of cultured cortical neurons through NRP1. A specific NRP1 inhibi...

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Autors principals: Jiang, Susan X., Whitehead, Shawn, Aylsworth, Amy, Slinn, Jacqueline, Zurakowski, Bogdan, Chan, Kenneth, Li, Jianjun, Hou, Sheng T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843238/
https://ncbi.nlm.nih.gov/pubmed/20133938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080689
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