A Conserved Active-site Threonine Is Important for Both Sugar and Flavin Oxidations of Pyranose 2-Oxidase

Pyranose 2-oxidase (P2O) catalyzes the oxidation by O(2) of d-glucose and several aldopyranoses to yield the 2-ketoaldoses and H(2)O(2). Based on crystal structures, in one rotamer conformation, the threonine hydroxyl of Thr(169) forms H-bonds to the flavin-N5/O4 locus, whereas, in a different rotam...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pitsawong, Warintra, Sucharitakul, Jeerus, Prongjit, Methinee, Tan, Tien-Chye, Spadiut, Oliver, Haltrich, Dietmar, Divne, Christina, Chaiyen, Pimchai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843219/
https://ncbi.nlm.nih.gov/pubmed/20089849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073247
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