Comparison of the effects of the new azalide antibiotic, azithromycin, and erythromycin estolate on rat liver cytochrome P-450.

Erythromycin and some other macrolide antibiotics can first induce a cytochrome P-450 isozyme similar to the one induced in rats by pregnenolone-16 alpha-carbonitrile and then inhibit it by forming a stable cytochrome P-450-metabolite complex. The purpose of this study was to compare azithromycin, a...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Amacher, D E, Schomaker, S J, Retsema, J A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284308/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656856/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.6.1186
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