Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease

Mutations in the progranulin gene (GRN) are causative for Frontotemporal Lobar Degeneration with ubiquitin-immunoreactive neuronal inclusions (FTLD-U). However, additional studies have demonstrated that these variants could be associated with Alzheimer's disease (AD). The influence of GRN genet...

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Main Authors: Fenoglio, Chiara, Galimberti, Daniela, Cortini, Francesca, Kauwe, John S.K., Cruchaga, Carlos, Venturelli, Eliana, Villa, Chiara, Serpente, Maria, Scalabrini, Diego, Mayo, Kevin, Piccio, Laura M., Clerici, Francesca, Albani, Diego, Mariani, Claudio, Forloni, Gianluigi, Bresolin, Nereo, Goate, Alison M., Scarpini, Elio
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842455/
https://ncbi.nlm.nih.gov/pubmed/19625741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1170
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