Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent

Endothelial cell migration is an essential aspect of tumor angiogenesis. Rac1 activity is needed for cell migration in vitro implying a requirement for this molecule in angiogenesis in vivo. However, a precise role for Rac1 in tumor angiogenesis has never been addressed. Here we show that depletion...

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Autori principali: D'Amico, Gabriela, Robinson, Stephen D., Germain, Mitchel, Reynolds, Louise E., Thomas, Gareth J., Elia, George, Saunders, Garry, Fruttiger, Marcus, Tybulewicz, Victor, Mavria, Georgia, Hodivala-Dilke, Kairbaan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842301/
https://ncbi.nlm.nih.gov/pubmed/20339539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009766
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