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Biochemical Characterization of the HpxO Enzyme from Klebsiella pneumoniae, a Novel FAD–Dependent Urate Oxidase

The HpxO enzyme from Klebsiella pneumoniae was recently proposed, on the basis of genetic studies, to catalyze the hydroxylation of uric acid to 5-hydroxyisourate as part of the purine catabolic pathway. Its primary sequence suggests that the HpxO catalytic activity depends on a flavin cofactor (FAD...

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Bibliografske podrobnosti
Main Authors: O’Leary, Seán E., Hicks, Katherine A., Ealick, Steven E., Begley, Tadhg P.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842088/
https://ncbi.nlm.nih.gov/pubmed/19260710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900160b
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