Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to chondroitin sulfate A (CSA) present on placental proteoglycans. Recent work implicates var2CSA, a member of the PfEMP1 family, as th...

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Autores principales: Srivastava, Anand, Gangnard, Stéphane, Round, Adam, Dechavanne, Sébastien, Juillerat, Alexandre, Raynal, Bertrand, Faure, Grazyna, Baron, Bruno, Ramboarina, Stéphanie, Singh, Saurabh Kumar, Belrhali, Hassan, England, Patrick, Lewit-Bentley, Anita, Scherf, Artur, Bentley, Graham A., Gamain, Benoît
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841952/
https://ncbi.nlm.nih.gov/pubmed/20194779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000951107
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