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Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions

Many of the mutations reported as potentially causing Lynch syndrome are missense mutations in human mismatch repair (MMR) genes. Here, we used a Saccharomyces cerevisiae-based system to study polymorphisms and suspected missense mutations in human MMR genes by modeling them at the appropriate S. ce...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Martinez, Sandra L., Kolodner, Richard D.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841877/
https://ncbi.nlm.nih.gov/pubmed/20176959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000798107
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