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Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions

Many of the mutations reported as potentially causing Lynch syndrome are missense mutations in human mismatch repair (MMR) genes. Here, we used a Saccharomyces cerevisiae-based system to study polymorphisms and suspected missense mutations in human MMR genes by modeling them at the appropriate S. ce...

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Detalhes bibliográficos
Main Authors: Martinez, Sandra L., Kolodner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841877/
https://ncbi.nlm.nih.gov/pubmed/20176959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000798107
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