THE LI FRAUMENI SYNDROME (LFS): A MODEL FOR THE INITIATION OF P53 SIGNATURES IN THE DISTAL FALLOPIAN TUBE

A candidate early precursor to pelvic serous cancer – the “p53 signature” – is commonly found in the benign mucosa of the distal fallopian tube and harbors p53 mutations and evidence of DNA damage. We examined tubes from women with pre-existing (germ-line) mutations in p53 (Li Fraumeni Syndrome or L...

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Huvudupphovsmän: Xian, Wa, Miron, Alexander, Roh, Michael, Semmel, Dana R., Yassin, Yosuf, Garber, Judy, Oliva, Esther, Goodman, Annekathryn, Mehra, Karishma, Berkowitz, Ross S., Crum, Christopher P, Quade, Bradley J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841524/
https://ncbi.nlm.nih.gov/pubmed/19834951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.2624
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