Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: Clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant

A live, cold-passaged (cp) candidate vaccine virus, designated respiratory syncytial virus (RSV) B1 cp-52/2B5 (cp-52), replicated efficiently in Vero cells, but was found to be overattenuated for RSV-seronegative infants and children. Sequence analysis of reverse-transcription–PCR-amplified fragment...

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Autori principali: Karron, Ruth A., Buonagurio, Deborah A., Georgiu, Alice F., Whitehead, Stephen S., Adamus, Jean E., Clements-Mann, Mary Lou, Harris, Denos O., Randolph, Valerie B., Udem, Stephen A., Murphy, Brian R., Sidhu, Mohinderjit S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC28415/
https://ncbi.nlm.nih.gov/pubmed/9391135
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