EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity

Airway inflammation and pulmonary disease are heterogeneous phenotypes in cystic fibrosis (CF) patients, even among patients with the same cystic fibrosis transmembrane conductance regulator (CFTR) genotype. Endothelin, a proinflammatory peptide and smooth muscle agonist, is increased in CF airways,...

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Hauptverfasser: Darrah, Rebecca, McKone, Edward, O'Connor, Clare, Rodgers, Christine, Genatossio, Alan, McNamara, Sharon, Gibson, Ronald, Stuart Elborn, J., Ennis, Madeleine, Gallagher, Charles G., Kalsheker, Noor, Aitken, Moira, Wiese, Dawn, Dunn, John, Smith, Paul, Pace, Rhonda, Londono, Douglas, Goddard, Katrina A. B., Knowles, Michael R., Drumm, Mitchell L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841492/
https://ncbi.nlm.nih.gov/pubmed/20028935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00185.2009
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