Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults study and the Cardiovascular Health Study

BACKGROUND: The transcription factor hepatocyte nuclear factor 1 (HNF-1) α regulates the activity of a number of genes involved in innate immunity, blood coagulation, lipid and glucose transport and metabolism, and cellular detoxification. Common polymorphisms of the HNF-1α gene (HNF1A) were recentl...

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Main Authors: Reiner, Alexander P., Gross, Myron D., Carlson, Christopher S., Bielinski, Suzette J., Lange, Leslie A., Fornage, Myriam, Jenny, Nancy S., Walston, Jeremy, Tracy, Russell P., Williams, O. Dale, Jacobs, David R., Nickerson, Deborah A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841292/
https://ncbi.nlm.nih.gov/pubmed/20031592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.108.839506
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