Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

BACKGROUND: Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morpholog...

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Detalhes bibliográficos
Main Authors: Jin, Jay, Kittanakom, Saranya, Wong, Victoria, Reyes, Beverly AS, Van Bockstaele, Elisabeth J, Stagljar, Igor, Berrettini, Wade, Levenson, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841195/
https://ncbi.nlm.nih.gov/pubmed/20214800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-33
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