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Agonist-Induced Endocytosis and Receptor Phosphorylation Mediate Resensitization of Dopamine D(2) Receptors
The regulatory mechanisms and functional roles of agonist-induced internalization of G protein-coupled receptors (GPCRs) were analyzed using mutant dopamine D(2) receptors (D(2)Rs) in which all possible GPCR kinase (GRK) phosphorylation sites were mutated or the affinity for β-arrestins was altered....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840813/ https://ncbi.nlm.nih.gov/pubmed/20160122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0369 |
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