Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

The ob/ob mouse is genetically deficient in leptin and exhibits a phenotype that includes obesity and non-insulin-dependent diabetes melitus. This phenotype closely resembles the morbid obesity seen in humans. In this study, we demonstrate that a single intramuscular injection of a recombinant adeno...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Murphy, John E., Zhou, Shangzhen, Giese, Klaus, Williams, Lewis T., Escobedo, Jaime A., Dwarki, Varavani J.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1997
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28408/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391128/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13921
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!