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Mitochondrial Stat3 Supports Ras-Dependent Oncogenic Transformation
STAT3 is a latent cytoplasmic transcription factor responsive to cytokine signaling and tyrosine kinase oncoproteins by nuclear translocation when tyrosine phosphorylated. We report that malignant transformation by activated Ras is impaired without STAT3, in spite of the inability of Ras to drive ST...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840701/ https://ncbi.nlm.nih.gov/pubmed/19556508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171721 |
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