Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation

p53, apoptosis, and senescence are frequently activated in preneoplastic lesions and are barriers to progression to malignancy. These barriers have been suggested to result from an ATM-mediated DNA damage response (DDR), which may follow oncogene-induced hyperproliferation and ensuing DNA replicatio...

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Detalhes bibliográficos
Main Authors: Reddy, Jay P., Peddibhotla, Sirisha, Bu, Wen, Zhao, Jing, Haricharan, Svasti, Du, Yi-Chieh Nancy, Podsypanina, Katrina, Rosen, Jeffrey M., Donehower, Larry A., Li, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840493/
https://ncbi.nlm.nih.gov/pubmed/20133707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910665107
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