Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

Human T cell leukemia/lymphotropic virus type I (HTLV-I) induces adult T cell leukemia/lymphoma (ATLL). The mechanism of HTLV-I oncogenesis in T cells remains partly elusive. In vitro, HTLV-I induces ligand-independent transformation of human CD4(+) T cells, an event that correlates with acquisition...

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Main Authors: Takemoto, Shigeki, Mulloy, James C., Cereseto, Anna, Migone, Thi-Sao, Patel, Barvin K. R., Matsuoka, Masao, Yamaguchi, Kuzunari, Takatsuki, Kiyoshi, Kamihira, Shimeru, White, Jeffrey D., Leonard, Warren J., Waldmann, Thomas, Franchini, Genoveffa
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC28404/
https://ncbi.nlm.nih.gov/pubmed/9391124
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