Anti-inflammatory triterpenoid blocks immune suppressive function of myeloid-derived suppressor cells and improves immune response in cancer

PURPOSE: Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore it would be important to identify effective therapeutic means to modulate these cells. EXPERIMENTAL DESIGN: We evaluated the effect of the synthetic triterpenoid C-28...

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Main Authors: Nagaraj, Srinivas, Youn, Je-In, Weber, Hannah, Iclozan, Cristina, Lu, Lily, Cotter, Matthew J., Meyer, Colin, Becerra, Carlos R., Fishman, Mayer, Antonia, Scott, Sporn, Michael B., Liby, Karen T., Rawal, Bhupendra, Lee, Ji-Hyun, Gabrilovich, Dmitry I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840181/
https://ncbi.nlm.nih.gov/pubmed/20215551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3272
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