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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle
Most carcinomas present some form of chromosome instability in combination with spindle defects. Numerical instability is likely caused by spindle aberrations, but the origin of breaks and translocations remains elusive. To determine whether one mechanism can bring about both types of instability, w...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840104/ https://ncbi.nlm.nih.gov/pubmed/20142474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912143106 |
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