Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

Most carcinomas present some form of chromosome instability in combination with spindle defects. Numerical instability is likely caused by spindle aberrations, but the origin of breaks and translocations remains elusive. To determine whether one mechanism can bring about both types of instability, w...

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Dades bibliogràfiques
Autors principals: Guerrero, Astrid Alonso, Gamero, Mercedes Cano, Trachana, Varvara, Fütterer, Agnes, Pacios-Bras, Cristina, Díaz-Concha, Nuria Panadero, Cigudosa, Juan Cruz, Martínez-A., Carlos, van Wely, Karel H. M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840104/
https://ncbi.nlm.nih.gov/pubmed/20142474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912143106
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