Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF

Kinases are known to regulate fundamental processes in cancer including tumor proliferation, metastasis, neovascularization, and chemoresistance. Accordingly, kinase inhibitors have been a major focus of drug development, and several kinase inhibitors are now approved for various cancer indications....

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Detalhes bibliográficos
Main Authors: Murphy, Eric A., Shields, David J., Stoletov, Konstantin, Dneprovskaia, Elena, McElroy, Michele, Greenberg, Joshua I., Lindquist, Jeff, Acevedo, Lisette M., Anand, Sudarshan, Majeti, Bharat Kumar, Tsigelny, Igor, Saldanha, Adrian, Walsh, Breda, Hoffman, Robert M., Bouvet, Michael, Klemke, Richard L., Vogt, Peter K., Arnold, Lee, Wrasidlo, Wolfgang, Cheresh, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840076/
https://ncbi.nlm.nih.gov/pubmed/20154271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909299107
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