Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth

The ability of human adipose tissue–derived mesenchymal stem cells (AT-MSCs), engineered to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase (CD::UPRT), to convert the relatively nontoxic 5-fluorocytosine (5-FC) into the highly toxic antitumor 5-fluorouracil (5-FU) toget...

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Autores principales: Cavarretta, Ilaria T, Altanerova, Veronika, Matuskova, Miroslava, Kucerova, Lucia, Culig, Zoran, Altaner, Cestmir
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839205/
https://ncbi.nlm.nih.gov/pubmed/19844197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.237
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