Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that may Discriminate Substrates During DNA Repair

Mre11 nuclease plays a central role in the repair of cytotoxic and mutagenic DNA double-strand breaks (DSBs). As x-ray structural information has only been available for the Pyrococcus furiosus enzyme (PfMre11), the conserved and variable features of this nuclease across the domains of life have not...

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Main Authors: Das, Debanu, Moiani, Davide, Axelrod, Herbert L., Miller, Mitchell D., McMullan, Daniel, Jin, Kevin K., Abdubek, Polat, Astakhova, Tamara, Burra, Prasad, Carlton, Dennis, Chiu, Hsiu-Ju, Clayton, Thomas, Deller, Marc C., Duan, Lian, Ernst, Dustin, Feuerhelm, Julie, Grant, Joanna C., Grzechnik, Anna, Grzechnik, Slawomir K., Han, Gye Won, Jaroszewski, Lukasz, Klock, Heath E., Knuth, Mark W., Kozbial, Piotr, Krishna, S. Sri, Kumar, Abhinav, Marciano, David, Morse, Andrew T., Nigoghossian, Edward, Okach, Linda, Paulsen, Jessica, Reyes, Ron, Rife, Christopher L., Sefcovic, Natasha, Tien, Henry J., Trame, Christine B., van den Bedem, Henry, Weekes, Dana, Xu, Qingping, Hodgson, Keith O., Wooley, John, Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Tainer, John A., Wilson, Ian A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839085/
https://ncbi.nlm.nih.gov/pubmed/20122942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.049
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