Relative Transmissibility of an R5 Clade C Simian-Human Immunodeficiency Virus Across Different Mucosae in Macaques Parallels the Relative Risks of Sexual HIV-1 Transmission Via Different Routes

BACKGROUND: Worldwide, ~90% of all HIV transmissions occur mucosally; almost all involve R5 strains. Risks of sexual HIV acquisition are highest for rectal, followed by vaginal and then oral exposures. METHODS: Mucosal lacerations may affect the rank-order of susceptibility to HIV but cannot be asse...

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Main Authors: Chenine, Agnès L., Siddappa, Nagadenahalli B., Kramer, Victor G., Sciaranghella, Gaia, Rasmussen, Robert A., Lee, Sandra J., Santosuosso, Michael, Poznansky, Mark C., Velu, Vijayakumar, Amara, Rama R., Souder, Chris, Anderson, Daniel C., Villinger, François, Else, James G., Novembre, Francis J., Strobert, Elizabeth, O’Neil, Shawn P., Secor, W. Evan, Ruprecht, Ruth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838976/
https://ncbi.nlm.nih.gov/pubmed/20214475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/651274
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