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Skp2B attenuates p53 function by inhibiting prohibitin
The F-box protein Skp2 and its isoform Skp2B are both overexpressed in breast cancers. Skp2 alters the activity of p53 by inhibiting its interaction with p300 and by promoting p300 degradation. Here, we report that Skp2B also attenuates the activity of p53; however, this effect is independent of p30...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838694/ https://ncbi.nlm.nih.gov/pubmed/20134482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.2 |
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