Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance

Tribbles homolog 3 (TRIB3) was found to inhibit insulin-stimulated Akt phosphorylation and modulate gluconeogenesis in rodent liver. Currently, we examined a role for TRIB3 in skeletal muscle insulin resistance. Ten insulin-sensitive, ten insulin-resistant, and ten untreated type 2 diabetic (T2DM) p...

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Autori principali: Liu, Jiarong, Wu, Xuxia, Franklin, John L., Messina, Joseph L., Hill, Helliner S., Moellering, Douglas R., Walton, R. Grace, Martin, Mitchell, Garvey, W. Timothy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838520/
https://ncbi.nlm.nih.gov/pubmed/19996382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00467.2009
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