Association of Plasma Leptin Levels with Incident Alzheimer’s Disease and MRI Measures Of Brain Aging: The Framingham Study

CONTEXT: The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes β-amyloid clearance and improves memory function in animal models of aging and Alzheimer’s disease (AD). OBJECTIVE: To relate baseline circulating leptin concentrations in a dementia...

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Hlavní autoři: Lieb, Wolfgang, Beiser, Alexa S., Vasan, Ramachandran S., Tan, Zaldy S., Au, Rhoda, Harris, Tamara B., Roubenoff, Ronenn, Auerbach, Sanford, DeCarli, Charles, Wolf, Philip A., Seshadri, Sudha
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838501/
https://ncbi.nlm.nih.gov/pubmed/20009056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2009.1836
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