Vesicular Stomatitis Virus Genomic RNA Persists In Vivo in the Absence of Viral Replication

Our previous studies using intranasal inoculation of mice with vesicular stomatitis virus (VSV) vaccine vectors showed persistence of vector genomic RNA (gRNA) for at least 60 days in lymph nodes in the absence of detectable infectious virus. Here we show high-level concentration of virus and gRNA i...

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Bibliographic Details
Main Authors: Simon, Ian D., van Rooijen, Nico, Rose, John K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838132/
https://ncbi.nlm.nih.gov/pubmed/20032173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02052-09
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