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Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences

p53 phosphorylation at Ser46 following DNA damage is important for preferential transactivation of proapoptotic genes. Here, we report that ataxia-telangiectasia mutated (ATM) kinase is responsible for Ser46 phosphorylation of p53 during early-phase response to DNA damage. To elucidate the direct ph...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kodama, Masami, Otsubo, Chihiro, Hirota, Toru, Yokota, Jun, Enari, Masato, Taya, Yoichi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838062/
https://ncbi.nlm.nih.gov/pubmed/20123963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00810-09
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