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Cholesterol seco-sterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration
[Image: see text] Cholesterol secosterol aldehydes inhibit the misfolding of a prion protein fragment that induces GSS in mice. Atheronal-B completely inhibits the α to β-form transformation of MoPrP(89-143, P101L) via a mechanism that involves adduction to the protein. This result offers a paradigm...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837945/ https://ncbi.nlm.nih.gov/pubmed/19899085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200904524 |
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