Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic–pharmacodynamic analysis from the IELSG no. 20 trial

BACKGROUND: This analysis was initiated to define the predictive value of the area under the curve of high-dose methotrexate (AUC(HD-MTX)) in patients with primary central nervous system lymphoma (PCNSL). PATIENTS AND METHODS: We included 55 patients with PCNSL and available pharmacokinetic (PK) dat...

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Detalhes bibliográficos
Main Authors: Joerger, M, Huitema, A D R, Krähenbühl, S, Schellens, J H M, Cerny, T, Reni, M, Zucca, E, Cavalli, F, Ferreri, A J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837574/
https://ncbi.nlm.nih.gov/pubmed/20125159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605559
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