Modeling Co-Expression across Species for Complex Traits: Insights to the Difference of Human and Mouse Embryonic Stem Cells

Complex interactions between genes or proteins contribute substantially to phenotypic evolution. We present a probabilistic model and a maximum likelihood approach for cross-species clustering analysis and for identification of conserved as well as species-specific co-expression modules. This model...

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Autors principals: Cai, Jun, Xie, Dan, Fan, Zhewen, Chipperfield, Hiram, Marden, John, Wong, Wing H., Zhong, Sheng
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837392/
https://ncbi.nlm.nih.gov/pubmed/20300647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000707
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