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Dabigatran, a direct thrombin inhibitor, blocks differentiation of normal fibroblasts to a myofibroblast phenotype and demonstrates anti-fibrotic effects on scleroderma lung fibroblasts

Myofibroblasts are the principal mesenchymal cells responsible for tissue remodeling, collagen deposition, and the restrictive nature of lung parenchyma associated with pulmonary fibrosis. We previously reported that thrombin activates protease-activated receptor (PAR)-1 thereby inducing normal lung...

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Bibliografiska uppgifter
Huvudupphovsmän: Bogatkevich, Galina S., Ludwicka-Bradley, Anna, Silver, Richard M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837365/
https://ncbi.nlm.nih.gov/pubmed/19877031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24935
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