The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R>Q154 amino acid substitution

The molecular basis of the HNA-3a/b (5b/a) leukocyte antigen system has not yet been defined despite evidence that HNA-3a–specific antibodies are particularly prone to cause severe, often fatal, transfusion-related lung injury. We used genome-wide single nucleotide polymorphism scanning and sequenci...

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Main Authors: Curtis, Brian R., Cox, Nancy J., Sullivan, Mia J., Konkashbaev, Anuar, Bowens, Krista, Hansen, Kirk, Aster, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
Assuntos:
Transfusion Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837332/
https://ncbi.nlm.nih.gov/pubmed/20040764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-248336
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