Activity of the cefotaxime (HR756) desacetyl metabolite compared with those of cefotaxime and other cephalosporins.

The desacetyl metabolite (DES) of cefotaxime (HR756) is formed in vivo to a significant extent. The in vitro activities of DES, the parent compound, and cefazolin, cefoxitin, and cefuroxime were compared against 70 bacterial isolates. DES was found to possess approximately 1/10th the activity of the...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Wise, R, Wills, P J, Andrews, J M, Bedford, K A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1980
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283730/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7352752/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.17.1.84
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