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Enrichment of homologs in insignificant BLAST hits by co-complex network alignment

BACKGROUND: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stringent score cutoff is applied to distinguish putative homologs from possible false positive hits. As a consequence, some...

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Detalhes bibliográficos
Main Authors: Fokkens, Like, Botelho, Sandra MC, Boekhorst, Jos, Snel, Berend
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836305/
https://ncbi.nlm.nih.gov/pubmed/20152020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-86
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