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Systematic Structure-Function Analysis of Androgen Receptor Leu(701) Mutants Explains the Properties of the Prostate Cancer Mutant L701H
One mechanism of prostate tumors for escape from androgen ablation therapies is mutation of the androgen receptor (AR). We investigated the unique properties of the AR L701H mutant, which is strongly stimulated by cortisol, by a systematic structure-function analysis. Most amino acid substitutions a...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836112/ https://ncbi.nlm.nih.gov/pubmed/20007693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039958 |
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