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Systematic Structure-Function Analysis of Androgen Receptor Leu(701) Mutants Explains the Properties of the Prostate Cancer Mutant L701H

One mechanism of prostate tumors for escape from androgen ablation therapies is mutation of the androgen receptor (AR). We investigated the unique properties of the AR L701H mutant, which is strongly stimulated by cortisol, by a systematic structure-function analysis. Most amino acid substitutions a...

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Bibliografiske detaljer
Main Authors: van de Wijngaart, Dennis J., Molier, Michel, Lusher, Scott J., Hersmus, Remko, Jenster, Guido, Trapman, Jan, Dubbink, Hendrikus J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836112/
https://ncbi.nlm.nih.gov/pubmed/20007693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039958
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