Spinal Endocannabinoids and CB(1) Receptors Mediate C-Fiber-Induced Heterosynaptic Pain Plasticity

Diminished synaptic inhibition in the spinal dorsal horn is a major contributor to chronic pain. Pathways, which reduce synaptic inhibition in inflammatory and neuropathic pain states, have been identified, but central hyperalgesia and diminished dorsal horn synaptic inhibition also occur in the abs...

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Hlavní autoři: Pernía-Andrade, Alejandro J., Kato, Ako, Witschi, Robert, Nyilas, Rita, Katona, István, Freund, Tamás F., Watanabe, Masahiko, Filitz, Jörg, Koppert, Wolfgang, Schüttler, Jürgen, Ji, Guangchen, Neugebauer, Volker, Marsicano, Giovanni, Lutz, Beat, Vanegas, Horacio, Zeilhofer, Hanns Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835775/
https://ncbi.nlm.nih.gov/pubmed/19661434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171870
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