The RGD Domain of Human Osteopontin Promotes Tumor Growth and Metastasis through Activation of Survival Pathways

BACKGROUND: Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function. Here, we use genetic approaches to systematically investigate the function of the RGD domain...

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Autors principals: Courter, Donald, Cao, Hongbin, Kwok, Shirley, Kong, Christina, Banh, Alice, Kuo, Peiwen, Bouley, Donna M., Vice, Carmen, Brustugun, Odd Terje, Denko, Nicholas C., Koong, Albert C., Giaccia, Amato, Le, Quynh-Thu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835762/
https://ncbi.nlm.nih.gov/pubmed/20224789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009633
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