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Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue

Induction of otic placodes requires Fgf from surrounding tissues. We tested the hypothesis that mesendodermally derived Bmp-antagonists Chordin, Follistatin-a and Crossveinless-2 cooperate in this process. Injecting morpholinos for all three genes, or treatment with the Nodal inhibitor SB431542 to b...

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Autors principals: Kwon, Hye-Joo, Riley, Bruce B.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835543/
https://ncbi.nlm.nih.gov/pubmed/19418450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21955
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